Rb1573-120910-WS

A synthetic peptide from n-terminal region (phospho S28) of human PSD93 (DLG2) conjugated to an immunogenic carrier protein was used as the antigen.

PSD93_HUMAN
PSD93_RAT
PSD93_MOUSE

DLG2, Disks large homolog 2, Channel associated protein of synapse 110, Chapsyn 110, Chapsyn-110, Postsynaptic density protein PSD-93

Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
Subcellular location: Membrane; Lipid-anchor. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Note: Concentrated in soma and postsynaptic density of a subset of neurons.
Tissue specificity: Brain. Highest levels of isoform1 in cortex, olfactory bulb, thalamus, hypothalamus, striatum and hippocampus. Highest level of isoform2 in olfactory bulb. Reduced levels in cortex and hippocampus. Highest level of isoform4 in spinal cord. Low levels of isoform4, isoform6, and isoform7 in superior cervical ganglion.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Kim E, et al. Neuron 17:103-113(1996)
2. Ko J, et al. Neuron 50:233-245(2006)
3. Lee H.W, et al. J. Neurosci. 28:14546-14556(2008)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for PSD93.

Human, rat, mouse. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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- Click to download the Material Safety Data Sheet