Rb1342-140310-WS

A synthetic peptide from extracellular domain of mouse Neuregulin-2 (NRG2) conjugated to an immunogenic carrier protein was used as the antigen.

NGR2_HUMAN
NGR2_MOUSE
NGR2_RAT

Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin 1, DON-1, NTAK

Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Subcellular location: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note: Does not seem to be active.
Neuregulin-2: Secreted
Tissue specificity: Expressed in most parts of the brain, especially the olfactory bulb and cerebellum where it localizes in granule and Purkinje cells. In the hippocampus, found in the granule cells of the dentate gyrus. In the basal forebrain, found in the cholinergic cells. In the hindbrain, weakly detectable in the motor trigeminal nucleus. Not detected in the hypothalamus. Also found in the liver and in the thymus. Not detected in heart, adrenal gland, or testis.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Carraway K.L, et al. Nature 387:512-516(1997)
2. Busfield S.J, et al. Mol. Cell. Biol. 17:4007-4014(1997)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for NRG2.

Human, mouse, rat. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet