Rb1942-281012-WS

A synthetic peptide from aa region 30-80 of human KCNJ6 conjugated to an immunogenic carrier protein was used as the antigen.

KCNJ6_HUMAN
KCNJ6_RAT
KCNJ6_MOUSE

G protein-activated inward rectifier potassium channel 2, GIRK2, Potassium channel, inwardly rectifying subfamily J member 6, Inward rectifier K(+) channel Kir3.2, KATP-2, BIR1, KATP2, KCNJ7

FUNCTION: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Tissue specificity: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
Subcellular location: Membrane, Multi-pass membrane protein.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Ferrer J, et al. J. Biol. Chem. 270:26086-26091(1995)
2. Schoots O, et al. Cell. Signal. 11:871-883(1999)
3. Sakura H, et al. FEBS Lett. 367:193-197(1995)
4. Tsaur M.-L, et al. Diabetes 44:592-596(1995)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for KCNJ6.

Human. Other species not yet tested but expected to work in rat and mouse.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet