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Code
OSS00227W
$240USD
ID Tag
Rb1293-140210-WS
Immunogen
A synthetic peptide from the n-terminal region of human SERCA1 (Calcium pump 1) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
AT2A1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase
Target
FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Defects in ATP2A1 are the cause of Brody myopathy (BRM). An autosomal recessive myopathy characterized by increasing impairment of relaxation of fast twist skeletal muscle during exercise.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity: Skeletal muscle, fast twitch muscle (type II) fibers.
Defects in ATP2A1 are the cause of Brody myopathy (BRM). An autosomal recessive myopathy characterized by increasing impairment of relaxation of fast twist skeletal muscle during exercise.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity: Skeletal muscle, fast twitch muscle (type II) fibers.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Zhang Y, et al. Genomics 30:415-424(1995)
2. Ota T, et al. Nat. Genet. 36:40-45(2004)
2. Ota T, et al. Nat. Genet. 36:40-45(2004)
Limitation
For research use only
Code
OSS00227W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for SERCA1.
Spcs X-react.
Human. Other species not yet tested but very likely to work in rat and mouse.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSS00227W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to SERCA1
