Code
OSP00104W
$240USD
ID Tag
Rb1222-051209-WS
Immunogen
A synthetic peptide from the c-terminal region of human KCNA5 (Potassium voltage-gated channel subfamily A member 5, Kv1.5) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Potassium voltage-gated channel subfamily A member 5, Voltage-gated potassium channel subunit Kv1.5, Voltage-gated potassium channel HK2, HPCN1
Target
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Pancreatic islets and insulinoma. Highly expressed in heart and moderately in brain. Low levels in thymus, skeletal muscle and spleen. Not expressed in liver, lung or kidney.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Tamkun M.M, et al. FASEB J. 5:331-337(1991)
2. Benson M.D, et al. Proc. Natl. Acad. Sci. U.S.A. 104:1805-1810(2007)
Limitation
For research use only
Code
OSP00104W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for KCNA5.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.