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Code
OSP00101W
$240USD
ID Tag
Rb1248-051209-WS
Immunogen
A synthetic peptide from c-terminal region of human KCNQ4 (Kv7.4) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Potassium voltage-gated channel subfamily KQT member 4, Voltage-gated potassium channel subunit Kv7.4, Potassium channel subunit alpha KvLQT4, KQT-like 4
Target
Function: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors.
Tissue specificity: Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
Subcellular location: Basal cell membrane; Multi-pass membrane protein. Note: Situated at the basal membrane of cochlear outer hair cells
Tissue specificity: Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
Subcellular location: Basal cell membrane; Multi-pass membrane protein. Note: Situated at the basal membrane of cochlear outer hair cells
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Kubisch C, et al. Cell 96:437-446(1999)
2. Gregory S.G, et al. Nature 441:315-321(2006)
2. Gregory S.G, et al. Nature 441:315-321(2006)
Limitation
For research use only
Code
OSP00101W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 200 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for KCNQ4.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSP00101W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to KCNQ4
