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Code
OSD00032W
$240USD
ID Tag
Rb1288-140210-WS
Immunogen
A synthetic peptide from the internal region of human Dorsal repulsive axon guidance protein (Draxin, Neucrin) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
DRAXI, Draxin, Neucrin, C1orf187
Target
FUNCTION: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway
SUBCELLULAR LOCATION: Secreted
TISSUE SPECIFICITY: Predominantly expressed in developing neural tissues. Expressed in many brain regions, including the olfactory bulb, cortex, midbrain, cerebellum and pontine nuclei in postnatal day 0 (P0). Detected in the dorsal spinal cord and commissural axons. In the forebrain commissures, it is expressed in the regions that surround the corpus callosum, hippocampal commissure, and anterior commissure, such as the midline glial cells, indusium griseum glia, and glial wedge.
SUBCELLULAR LOCATION: Secreted
TISSUE SPECIFICITY: Predominantly expressed in developing neural tissues. Expressed in many brain regions, including the olfactory bulb, cortex, midbrain, cerebellum and pontine nuclei in postnatal day 0 (P0). Detected in the dorsal spinal cord and commissural axons. In the forebrain commissures, it is expressed in the regions that surround the corpus callosum, hippocampal commissure, and anterior commissure, such as the midline glial cells, indusium griseum glia, and glial wedge.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Clark H.F, et al. Genome Res. 13:2265-2270(2003)
2. Gregory S.G, et al. Nature 441:315-321(2006)
3. Zhang Z, et al. Protein Sci. 13:2819-2824(2004)
2. Gregory S.G, et al. Nature 441:315-321(2006)
3. Zhang Z, et al. Protein Sci. 13:2819-2824(2004)
Limitation
For research use only
- Click to download the Data Sheet
⚬ Products
Rabbit antibody to Neucrin
