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Code
OSS00211W
$240USD
ID Tag
Rb1237-051209-WS
Immunogen
A synthetic peptide from PDZ region of human SHANK3 (ProSAP2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 90% identity with rat and mouse sequences.
Accession
Also known
SH3 and multiple ankyrin repeat domains protein 3, ProSAP2, Proline rich synapse associated protein 2, PSAP2
Target
Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Subcellular location: Cytoplasm. Cell junction ⺠synapse. Cell junction ⺠synapse ⺠postsynaptic cell membrane ⺠postsynaptic density. Note: Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.
Tissue specificity: Widely expressed in brain.
Subcellular location: Cytoplasm. Cell junction ⺠synapse. Cell junction ⺠synapse ⺠postsynaptic cell membrane ⺠postsynaptic density. Note: Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.
Tissue specificity: Widely expressed in brain.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Dunham I, et al. ature 402:489-495(1999)
2. Zahedi R.P, et al. J. Proteome Res. 7:526-534(2008)
2. Zahedi R.P, et al. J. Proteome Res. 7:526-534(2008)
Limitation
For research use only
Code
OSS00211W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for SHANK3.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSS00211W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to SHANK3
