CCM2 antibody, Malcavernin antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

Immunology

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSM00078W

$240USD

ID Tag

Rb1211-051209-WS

Immunogen

A synthetic peptide from the n-terminal region of mouse Malcavernin (CCM2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat.

Accession

EDNRB_MOUSE
EDNRB_HUMAN
EDNRB_RAT

Also known

CCM2, Cerebral cavernous malformations protein 2 homolog, Osmosensing scaffold for MEKK3, Osm

Target

FUNCTION: May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
Subcellular location: Cytoplasm. Note: Treatment with sorbitol caused relocalization to ruffle-like structures.
Tissue specificity: Highly expressed in heart, lower expression in kidney, lung and liver (at protein level).

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Uhlik M.T, et al. Nat. Cell Biol. 5:1104-1110(2003)
2. Carninci P, et al. Science 309:1559-1563(2005)
3. Church D.M, et al. PLoS Biol. 7:E1000112-E1000112(2009)

Limitation

For research use only

Code

OSM00078W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for Malcavernin.

Spcs X-react.

Human, rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSM00078W