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Code
OSC00192W
$240USD
ID Tag
Rb1228-051209-WS
Immunogen
A synthetic peptide from extracellular domain of human Contactin associated protein like 2 (CNTNAP2) conjugated to blue carrier protein was used as the antigen.
Accession
Also known
CNTP2, Cell recognition molecule Caspr2, CNTNAP2, CASPR2
Target
FUNCTION: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.
Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES). Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein
Tissue specificity: Predominantly expressed in nervous system.
Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES). Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein
Tissue specificity: Predominantly expressed in nervous system.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Poliak S, et al. Neuron 24:1037-1047(1999)
Limitation
For research use only
Code
OSC00192W
$240USD
Unit size
100 ul
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for CNTNAP2.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSC00192W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to CNTNAP2
