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Code
OSC00178W
$240USD
ID Tag
Rb1106-130909-WS
Immunogen
A synthetic peptide from aa region 40-80 of human Complexin-2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Accession
Also known
CPLX2, Complexin II, CPX II, Synaphin-1, Complexin 2
Target
FUNCTION: Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis.
SUBCELLULAR LOCATION: Cytoplasm ⺠cytosol. Note: Enriched at synaptic-releasing sites in mature neurons.
Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
SUBCELLULAR LOCATION: Cytoplasm ⺠cytosol. Note: Enriched at synaptic-releasing sites in mature neurons.
Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. McMahon H.T, et al. Cell 83:111-119(1995)
2. Ota T, et al. Nat. Genet. 36:40-45(2004)
2. Ota T, et al. Nat. Genet. 36:40-45(2004)
Limitation
For research use only
Code
OSC00178W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 3000 to 1 : 4000 is recommended for WB and 1:1000 to 1:2000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for Complexin-2.
Spcs X-react.
Mouse, rat, human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
- Click to see the eLab Book
Code
OSC00178W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
Code
OSC00178W
$240USD
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WB on rat tissue lysates. Blocking: 1% LFDM for 30 min at RT; primary antibody: dilution 1:3000 incubated at 4C overnight. Click on eLAB BOOK tab to see the details. |
⚬ Products
Rabbit antibody to Complexin-2 (40-80)
