Rb1116-130909-WS

A synthetic peptide to n-terminal region of human Rab3-interacting molecule 1 (RIMS1, RIM1) conjugated to an immunogenic carrier protein was used as the antigen.

Regulating synaptic membrane exocytosis protein 1, RIMS1, RIM 1, RIM1

FUNCTION: Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction › synapse. Cell junction › synapse › presynaptic cell membrane; Peripheral membrane protein
Tissue specificity: Detected in brain and retina.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Johnson S, et al. Genomics 81:304-314(2003)
2. Nagase T, et al. DNA Res. 4:141-150(1997)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for RIM1.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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