Nogo antibody, RTN4 antibody, Reticulon-4 antibody, Reticulon-5 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSN00031W

$240USD

ID Tag

Gt170-160809-WS

Immunogen

A synthetic peptide from internal region of human Nogo conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

Accession

NOGO_HUMAN
NOGO_RAT
NOGO_MOUSE

Also known

RTN4, Neurite outgrowth inhibitor, Reticulon-4, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5

Target

Function: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Yang J, et al. Cytogenet. Cell Genet. 88:101-102(2000)
2. Prinjha R, et al. Nature 403:383-384(2000)

Limitation

For research use only

Code

OSN00031W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

Goat

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for Nogo.

Spcs X-react.

Human, rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSN00031W