CNGB3 antibody, CNG channel beta-3 antibody, Cyclic nucleotide-gated channel beta-3 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSC00176W

$240USD

ID Tag

Rb1050-020809-WS

Immunogen

A synthetic peptide from the c-terminal region of human CNGB3 conjugated to blue carrier protein was used as the antigen.

Accession

CNGB3_HUMAN

Also known

CNGB3, Cyclic nucleotide-gated cation channel beta-3, Cyclic nucleotide-gated channel beta-3, Cone photoreceptor cGMP-gated channel subunit beta, Cyclic nucleotide-gated cation channel modulatory subunit

Target

FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Subcellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed specifically in the retina.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Kohl S, et al. Hum. Mol. Genet. 9:2107-2116(2000)

Limitation

For research use only

Code

OSC00176W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for CNGB3.

Spcs X-react.

Human. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSC00176W