ERAB antibody, Mitochondrial Marker, Mitochondrial Marker antibody, HADH2 antibody, Mitochondrial ribonuclease P protein 2 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSE00028W

$240USD

ID Tag

Rb1027-280609-WS

Immunogen

A synthetic peptide from the internal region of human 3-hydroxyacyl-CoA dehydrogenase type-2 (ERAB) conjugated to an immunogenic carrier protein was used as the immunogen.

Accession

ERAB_HUMAN

Also known

HCD2, 3-hydroxyacyl-CoA dehydrogenase type II, Type II HADH, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 17-beta-hydroxysteroid dehydrogenase 10, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, Short-chain type dehydrogenase/reductase XH98G2, HSD17B10, ERAB, HADH2, MRPP2, SCHAD, XH98G2

Target

FUNCTION: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
SUBCELLULAR LOCATION: Mitochondrion
Tissue specificity: Expressed in normal tissues but is overexpressed in neurons affected in AD.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Yan S.D, et al. Nature 389:689-695(1997)
2. Lenski C, et al. Am. J. Hum. Genet. 80:372-377(2007)
3. Froyen G, et al. Am. J. Hum. Genet. 82:432-443(2008)

Limitation

For research use only

Code

OSE00028W

$240USD

Unit size

150 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for ERAB.

Spcs X-react.

Human. Not yet tested in other species.

Format

Lyophilised

Reconstitution

Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSE00028W