CNG1 antibody, CNG channel alpha-1 antibody, CNG-1 antibody, CNG 1 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSC00162W

$240USD

ID Tag

Rb1041-020809-WS

Immunogen

A synthetic peptide from aa region 50-100 of human CNGA1 conjugated to blue carrier protein was used as the antigen.

Accession

CNGA1_HUMAN

Also known

CNGA1, cGMP-gated cation channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel alpha-1, Cyclic nucleotide-gated channel, photoreceptor, Cyclic nucleotide-gated cation channel 1, Rod photoreceptor cGMP-gated channel subunit alpha, CNCG, CNCG1

Target

FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Rod cells in the retina.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Pittler S.J, et al. J. Biol. Chem. 267:6257-6262(1992)

Limitation

For research use only

Code

OSC00162W

$240USD

Unit size

100 ul

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for CNGA1.

Spcs X-react.

Human. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSC00162W