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Code
OSC00159W
$240USD
ID Tag
Rb1013-280609-WS
Immunogen
A synthetic peptide from aa region 2-50 of human CBY1 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Protein chibby homolog 1, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1, PIGEA-14, Cytosolic leucine-rich protein, ARPP-binding protein, ARB1, CBY, PGEA1
Target
FUNCTION: Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Tissue specificity: Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
Tissue specificity: Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Wiemann S, et al. Genome Res. 11:422-435(2001)
2. Collins J.E, et al. Genome Res. 13:27-36(2003)
3. Ota T, et al. Nat. Genet. 36:40-45(2004)
4. Dunham I, et al. Nature 402:489-495(1999)
5. Hidaka S, et al. J. Biol. Chem. 279:35009-35016(2004)
2. Collins J.E, et al. Genome Res. 13:27-36(2003)
3. Ota T, et al. Nat. Genet. 36:40-45(2004)
4. Dunham I, et al. Nature 402:489-495(1999)
5. Hidaka S, et al. J. Biol. Chem. 279:35009-35016(2004)
Limitation
For research use only
Code
OSC00159W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for CBY1.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSC00159W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to CBY1
