Anti VGLUT3 antibody, Vesicular glutamate transporter 3 antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

Immunology

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Histology / Detection

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OVERVIEW
SPECS
CONTROL PEPTIDE
eLAB BOOK
MSDS/DS
IMAGES

Code

OSV00056W

$240USD

ID Tag

Rb3373-131218-WS

Immunogen

A synthetic peptide to n-terminal region of human VGluT3 conjugated to blue carrier protein was used as the antigen.

Accession

VGLUT3_HUMAN
VGLUT3_RAT
VGLUT3_MOUSE

Also known

Vesicular glutamate transporter 3, Solute carrier family 17 member 8

Target

FUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Defects in SLC17A8 are the cause of non-syndromic sensorineural deafness autosomal dominant type 25 (DFNA25). DFNA25 is a form of sensorineural hearing loss. The expression of DFNA25 deafness is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged.
SUBCELLULAR LOCATION: Cytoplasmic vesicle âº secretory vesicle âº synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction âº synapse âº synaptosome
TISSUE SPECIFICITY: Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Takamori S, et al. EMBO Rep. 3:798-803(2002)

Limitation

For research use only

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OSV00109W	Guinea pig antibody to VGluT3

Code

OSV00056W

$240USD

IHC-P on paraffin sections of mouse brain. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 ml 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chromogen from Osenses. Primary antibody: dilution 1: 250, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin.

IHC-P on paraffin sections of rat hippocampus. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 ml 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chromogen from Osenses. Primary antibody: dilution 1: 250, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin.

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Rabbit antibody to VGluT3