Rb958-280609-WS

A synthetic peptide from aa region 100-150 of human P2RY5 conjugated to blue carrier protein was used as the antigen.

P2RY5_HUMAN
P2RY5_RAT
P2RY5_MOUSE

P2Y purinoceptor 5, P2RY5, Purinergic receptor 5, ATP receptor, Oleoyl-L-alpha-lysophosphatidic acid receptor, RB intron encoded G-protein coupled receptor

FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Defects in P2RY5 are a cause of autosomal recessive woolly hair (ARWH). Woolly hair refers to a phenotypic variant with fine and tightly curled hair. Defects in P2RY5 are the cause of localized autosomal recessive hypotrichosis type 3 (LAH3). LAH3 is a form of hereditary isolated alopecia characterized by diffuse and progressive hair loss, usually beginning in early childhood.
Tissue specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes. Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.
Subcellular location: Membrane; Multi-pass membrane protein.

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Toguchida J, et al. Genomics 17:535-543(1993)

For research use only

100 ul

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for P2RY5.

Human, rat, mouse. Other species not yet tested.

Lyophilised

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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