SCN8A antibody, Nav1.6 antibody, Sodium channel protein type 8 subunit alpha antibody

Primary Antibodies

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSS00154W

$240USD

ID Tag

Rb941-240509-WS

Immunogen

A synthetic peptide from the c-terminal region of human Sodium channel protein type 8 subunit alpha (SCN8A, Nav1.6) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse and rat.

Accession

SCN8A_HUMAN
SCN8A_MOUSE
SCN8A_RAT

Also known

Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6, SCN8A, MED, Nav1.6

Target

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na⁺ ions may pass in accordance with their electrochemical gradient.
Tissue specificity: Expressed in brain, cerebellum and spinal cord.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Plummer N.W, et al. J. Biol. Chem. 272:24008-24015(1997)
2. Plummer N.W, et al. Genomics 54:287-296(1998)
3. Fotia A.B, et al. J. Biol. Chem. 279:28930-28935(2004)

Limitation

For research use only

Code

OSS00154W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for SCN8A.

Spcs X-react.

Human, rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSS00154W