KCNK18 antibody, TRESK antibody, KCNKI antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

G Protein Signaling

Hydra Proteins

Immunology

Ion Channels & pumps

Microbiology

Neuroscience

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSK00051W

$240USD

ID Tag

Rb922-260409-WS

Immunogen

A synthetic peptide from the n-terminal region of mouse KCNK18 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

KCNK18_MOUSE
KCNK18_RAT

Also known

Potassium channel subfamily K member 18, Two-pore-domain potassium channel TRESK, KCNKI

Target

Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K⁺ currents. May function as background potassium channel that sets the resting membrane potential. Inhibited by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is enhanced by high cytoplasmic calcium levels, due to activation of the protein phosphatase calcineurin. The volatile anestetic isoflurane enhances potassium currents.
Tissue specificity: Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis.
Subcellular location: Membrane, Multi-pass membrane protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Czirjak G, et al. J. Biol. Chem. 279:18550-18558(2004)
2. Keshavaprasad B, et al. Anesth. Analg. 101:1042-1049(2005)

Limitation

For research use only

Code

OSK00051W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for KCNK18.

Spcs X-react.

Mouse, rat. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSK00051W