KCNK1 antibody, TWIK-1 antibody, TWIK1 antibody, TWIK-1 antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

G Protein Signaling

Hydra Proteins

Immunology

Ion Channels & pumps

Microbiology

Neuroscience

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSK00037W

$240USD

ID Tag

Rb908-260409-WS

Immunogen

A synthetic peptide from aa region 10-70 of mouse KCNK1 (TWIK-1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat.

Accession

KCNK1_MOUSE
KCNK1_HUMAN
KCNK1_RAT

Also known

Potassium channel subfamily K member 1, Inward rectifying potassium channel protein TWIK-1

Target

Function: Weak inwardly rectifying potassium channel. Inhibited by quinine, barium, and internal acidification. Activated by protein kinase C.
Tissue specificity: Widely expressed. Highest expression in brain, kidney, thyroid, salivary gland, adrenal gland, prostate, epididymis, uterus, placenta, colon and jejunum. Moderate expression in eyes, pituitary, pancreas, smooth muscle, testis and ovary. Very low levels in lung, aorta, liver, heart, skeletal muscle, thymus and spleen. In the brain, highest expression in cerebellar granule cells, brainstem, hippocampus and cerebral cortex.
Subcellular location: Membrane, Multi-pass membrane protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Lesage F, et al. FEBS Lett. 402:28-32(1997)
2. Arrighi I, et al. FEBS Lett. 425:310-316(1998)
3. Munton R.P, et al. Mol. Cell. Proteomics 6:283-293(2007)

Limitation

For research use only

Code

OSK00037W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for KCNK1.

Spcs X-react.

Human, rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Code

GSP00005P

$120USD

ID Tag

65641-72

Unit size

50 Âµg

Accession

KCNK1_MOUSE
KCNK1_HUMAN
KCNK1_RAT

Also known

Potassium channel subfamily K member 1, Inward rectifying potassium channel protein TWIK-1

Target

This is the immunising peptide for the product Rabbit antibody to n-terminal region of KCNK1 (TWIK-1): whole serum (GSP00005P)

Purity

>85%

Applications

Control peptide

Format

Lyophilised

Reconstitution

This peptide is soluble in water.

Storage

Maintain refrigerated at 2-8°C for up to 12 months. After reconstitution keep at -20°C. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Lesage F, et al. FEBS Lett. 402:28-32(1997)
2. Arrighi I, et al. FEBS Lett. 425:310-316(1998)
3. Munton R.P, et al. Mol. Cell. Proteomics 6:283-293(2007)
4. Gregory S.G, et al. Nature 441:315-321(2006)
5. Orias M, et al. Am. J. Physiol. 273:F663-F666(1997)

Limitation

For research use only