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Code
OSH00014W
$240USD
ID Tag
Rb843-290309-WS
Immunogen
A synthetic peptide from mature region of human Hepcidin (HAMP) conjugated to an immunogenic carrier protein has been used as the antigen.
Accession
Also known
Hepcidin, Liver-expressed antimicrobial peptide, LEAP-1, Putative liver tumor regressor, HAMP, HEPC, LEAP1
Target
FUNCTION: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
SUBCELLULAR LOCATION: Secreted.
Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.
SUBCELLULAR LOCATION: Secreted.
Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Park C.H, et al. J. Biol. Chem. 276:7806-7810(2001)
2. Krause A, et al. FEBS Lett. 480:147-150(2000)
3. Clark H.F, et al. Genome Res. 13:2265-2270(2003)
4. Grimwood J, et al. Nature 428:529-535(2004)
5. Delatycki M.B, et al. Clin. Genet. 65:378-383(2004)
2. Krause A, et al. FEBS Lett. 480:147-150(2000)
3. Clark H.F, et al. Genome Res. 13:2265-2270(2003)
4. Grimwood J, et al. Nature 428:529-535(2004)
5. Delatycki M.B, et al. Clin. Genet. 65:378-383(2004)
Limitation
For research use only
Code
OSH00014W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. Use at a dilution of 1:100 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for Hepcidin.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSH00014W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Rabbit antibody to Hepcidin
