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Code
OSD00019G
$240USD
ID Tag
Sh130-070309-G
Immunogen
A synthetic peptide from aa region 120-170 of human DCTN1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and moue.
Accession
Also known
DAP-150, DP-150, p150-glued,p135, Dynactin subunit 1, 150 kDa dynein-associated polypeptide
Target
FUNCTION: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
SUBUNIT: Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Brain.
DISEASE: Defects in DCTN1 are the cause of progressive lower motor neuron disease. PLMND is a progressive dominant disease that has no sensory symptoms.
SUBUNIT: Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Brain.
DISEASE: Defects in DCTN1 are the cause of progressive lower motor neuron disease. PLMND is a progressive dominant disease that has no sensory symptoms.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Collin G.B, et al. Genomics 53:359-364(1998).
2. Bu W, et al. J. Biol. Chem. 278:49721-49731(2003).
2. Bu W, et al. J. Biol. Chem. 278:49721-49731(2003).
Limitation
For research use only
Related
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Code
OSD00019G
$240USD
Unit size
500 µg
Conjugate
Unconjugated antibody
Host
Sheep
Purity
IgG
Clonality
Polyclonal
Isotype
Polyclonal, IgG
Applications
IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for DCTN1.
Spcs X-react.
Human, Mouse, rat. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSD00019G
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Sheep antibody to DCTN1
