Rb653-060908-G

A synthetic peptide from the c-terminal region of mouse CHMP6 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity with rat's.

CHMP6_MOUSE
CHMP6_RAT

Charged multivesicular body protein 6, Chromatin-modifying protein 6

FUNCTION: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In the ESCRT-III complex, it probably serves as an acceptor for ESCRT-II complex on endosomal membranes.
SUBUNIT: Component of the endosomal sorting required for transport complex III (ESCRT-III), at least composed of CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3/VPS24, CHMP4A/SHAX2, CHMP4B/SHAX1, CHMP4C/SHAX3, CHMP5/SNF7DC2 and CHMP6/VPS20. In the complex, it interacts directly with CHMP4A, CHMP4B and CHMP4C. Interacts directly with SNF8, VPS25 and VPS36 components of the ESCRT-II complex.
SUBCELLULAR LOCATION: Intracytoplasmic membrane. Endosome membrane; Lipid-anchor . Note: Localizes to endosomal membranes.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Watahiki A, et al. Nat. Methods 1 (3), 233-239(2004).

For research use only

	Code Product Name OSC00049W Rabbit antibody to CHMP6

500 µg

Unconjugated antibody

NZ white rabbit

IgG

Polyclonal

Polyclonal, IgG

IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for CHMP6.

Mouse, rat. Other species not yet tested.

Lyophilised

Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet