Rb805-140209-G

A synthetic peptide from human CACNA1E (Cav2.3) conjugated to blue carrier protein was used as the antigen.

CACNA1E_HUMAN
CACNA1E_MOUSE
CACNA1E_RAT

Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha Cav2.3, Calcium channel, L type, alpha-1 polypeptide, Brain calcium channel II, CACH6, CACNL1A6

Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Expressed in neuronal tissues and in kidney.

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Schneider T, et al. Recept. Channels 2:255-270(1994)

For research use only

	Code Product Name OSC00085W Rabbit antibody to CACNA1E

500 ug

Unconjugated antibody

NZ white rabbit

IgG

Polyclonal

Polyclonal, IgG

IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.

Specific for CACNA1E.

Human, rat, mouse. Other species not yet tested.

Lyophilised

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet