Rb803-140209-G

A synthetic peptide from aa region 50-100 of human CACNA1C conjugated to blue carrier protein was used as the antigen. The antigen shares 96% identity with mouse, rat and rabbit sequence.

CACNA1C_HUMAN
CACNA1C_MOUSE
CACNA1C_RAT

CACH2, CACN2, CACNL1A1, CCHL1A1, Voltage-gated calcium channel subunit alpha Cav1.2, Calcium channel, L type, alpha-1 polypeptide, cardiac muscle, Voltage dependent L-type calcium channel subunit alpha-1C

Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Schultz D, et al. Proc. Natl. Acad. Sci. U.S.A. 90:6228-6232(1993)

For research use only

	Code Product Name OSC00081W Rabbit antibody to CACNA1C (50-100)

500 ug

Unconjugated antibody

NZ white rabbit

IgG

Polyclonal

Polyclonal, IgG

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.

Specific for CACNA1C.

Human, rat, mouse. Other species not yet tested.

Lyophilised

Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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