Rb801-140209-WS

A synthetic peptide from aa region 1000-1050 of human CACNA1A conjugated to blue carrier protein was used as the antigen. The antigen shares 87% identity with mouse and rat sequence.

CACNA1A_HUMAN
CACNA1A_MOUSE
CACNA1A_RAT

BI, Brain calcium channel I, Cach4, Cacn3, Cacna1a, Cacnl1a4, Calcium channel L type alpha-1 polypeptide, Voltage-dependent P/Q-type calcium channel alpha-1A subunit, Voltage-gated calcium channel alpha subunit Cav2.1

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Tissue specificity: Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Hans M, et al. Biophys. J. 76:1384-1400(1999)
2. Ophoff R.A, et al. Cell 87:543-552(1996)

For research use only

	Code Product Name OSC00256W Rabbit antibody to CACNA1A OSC00271W Rabbit antibody to CACNA1A (2150-2210)

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.

Specific for CACNA1A.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

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