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Code
OSR00317W
$240USD
ID Tag
Rb791-140209-WS
Immunogen
A synthetic peptide from the internal region of human Rho related GTP binding protein RhoU (CDC42 like GTPase 1, CDC42L1, Ryu GTPase) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 90% identity with rat and mouse sequence.
Accession
Also known
Rho related GTP binding protein RhoU, RhoU, Ryu GTPase, CDC42-like GTPase 1, Rho GTPase-like protein ARHU, GTP-binding protein-like 1, ARHU, CDC42L1, G28K, WRCH1, Wnt-1 responsive Cdc42 homolog 1
Target
Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound.
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction ⺠focal adhesion. Cell projection ⺠podosome. Note: Localizes to podosomes in SRC-transformed cells.
Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction ⺠focal adhesion. Cell projection ⺠podosome. Note: Localizes to podosomes in SRC-transformed cells.
Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Tao W, et al. Genes Dev. 15:1796-1807(2001)
2. Bubb K.L, et al. Genetics 173:2165-2177(2006)
2. Bubb K.L, et al. Genetics 173:2165-2177(2006)
Limitation
For research use only
Related
products
products
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Code
OSR00317W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for RhoU.
Spcs X-react.
Human, mouse, rat. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSR00317W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Rabbit antibody to RhoU
