Rb726-221108-WS

A synthetic peptide from human KCNT1 conjugated to blue carrier protein was used as the antigen.

KCNT1_HUMAN
KCNT1_MONKEY

Potassium channel subfamily T member 1, KCa4.1, SLACK

FUNCTION: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K⁺. May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca²⁺ or Mg²⁺.
Subcellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Testis-specific. Mainly expressed in spermatocytes.
Detected in brain and brainstem, in vestibular and oculomotor nuclei, the medial nucleus of the trapezoid in the auditory system, in olfactory bulb, red nucleus, and deep cerebellar nuclei. Detected in thalamus, substantia nigra, and amygdala (at protein level). Highly expressed in the brain and kidney.
Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Humphray S.J, et al. Nature 429:369-374(2004)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 3000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for KCNT1.

Human, marmoset. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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