phospho Y820 TrkC antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OST00234G

$260USD

ID Tag

Rb679-060908-G

Immunogen

A synthetic peptide to phospho Y820 of human TrkC conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and mouse. The peptide is homologous in rat and mouse.

Accession

TRKC_HUMAN
TRKC_RAT
TRKC_MOUSE

Also known

Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3

Target

FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Merlio J.P, et al. Neuroscience 51:513-532(1992).
8. Ultsch M.H, et al. J. Mol. Biol. 290:149-159(1999).

Limitation

For research use only

Related
products

Code	Product Name
OST00233W	Rabbit antibody to phospho Y820 TrkC

Code

OST00234G

$260USD

Unit size

500 ug

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

IgG

Clonality

Polyclonal

Isotype

Polyclonal, IgG

Applications

IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. This antibody may also recognise the unphosphorylated form.

Specificity

Specific for TrkC.

Spcs X-react.

Rat, mouse, human. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OST00234G