|
|
Code
OSN00012W
$240USD
ID Tag
Rb697-060908-WS
Immunogen
A synthetic peptide from c-terminal of mouse Nexin-1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and human.
Accession
Also known
Nexin 1, SNX1, Nexin-1
Target
FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with PtdIns(3,4,5)P3 and, with weaker affinity, with PtdIns(3,5)P2.
SUBCELLULAR LOCATION: Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
SUBCELLULAR LOCATION: Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Nakamura N, et al. J. Biochem. 130:765-771(2001).
2. Chin L.-S, et al. J. Biol. Chem. 276:7069-7078(2001).
3. Zody M.C, et al. Nature 440:671-675(2006).
2. Chin L.-S, et al. J. Biol. Chem. 276:7069-7078(2001).
3. Zody M.C, et al. Nature 440:671-675(2006).
Limitation
For research use only
- Click to download the Data Sheet
⚬ Products
Rabbit antibody to Nexin 1
