Rb298-230208-G

A synthetic peptide from aa region 300-360 of human SQSTM1 has been used as the antigen.

Sequestosome 1, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, p60, EBIAP, SQSTM1, A170, OSIL, PDB3, ZIP3, p62B

FUNCTION: Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Nucleus. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.
TISSUE SPECIFICITY: Ubiquitously expressed.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Devergne O, et al. J. Virol. 70:1143-1153(1996).
2. Joung I, et al. Proc. Natl. Acad. Sci. U.S.A. 93:5991-5995(1996).

For research use only

	Code Product Name OSS00007W Rabbit antibody to SQSTM1 (300-360) OSS00006W Sheep antibody to SQSTM1 (300-360) OSS00084G Sheep antibody to SQSTM1 (300-360)

500 µg

Unconjugated antibody

NZ white rabbit

IgG

Polyclonal

Polyclonal, IgG

IHC (both on frozen and paraffin embedded tissues), WB. Use at a concentration of 10-50 µg/ml. The optimal concentration should be determined by the end user.

Specific for sequestosome-1.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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- Click to download the Material Safety Data Sheet