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Code
OST00217W
$240USD
ID Tag
Sh114-140908-WS
Immunogen
A synthetic from the 4th cytoplasmic loop of human transient receptor potential cation channel subfamily A member 1 (TRPA1, ANKTM1) conjugated to an immunogenic carrier protein was used as the antigen.
The location of the immunogen is highlighted in green.
The location of the immunogen is highlighted in green.
Accession
Also known
Transient receptor potential cation channel subfamily A member 1, ankyrin-like with transmembrane domains protein 1, transformation sensitive protein p120, ANKTM1
Target
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
FUNCTION: Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
TISSUE SPECIFICITY: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
MISCELLANEOUS: Inhibited by ruthenium red, a potent blocker of TRPV channels.
FUNCTION: Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
TISSUE SPECIFICITY: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
MISCELLANEOUS: Inhibited by ruthenium red, a potent blocker of TRPV channels.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Jaquemar D, et al. J. Biol. Chem. 274:7325-7333(1999).
2. Dai Y, et al. J. Clin. Invest. 117 (7), 1979-1987 (2007).
3. Hinman A, et al. Proc. Natl. Acad. Sci. U.S.A. 103 (51), 19564-19568 (2006).
4. Clapham D.E, et al. Pharmacol. Rev. 57 (4), 427-450 (2005).
5. Jaquemar D, et al. J. Biol. Chem. 274 (11), 7325-7333 (1999).
2. Dai Y, et al. J. Clin. Invest. 117 (7), 1979-1987 (2007).
3. Hinman A, et al. Proc. Natl. Acad. Sci. U.S.A. 103 (51), 19564-19568 (2006).
4. Clapham D.E, et al. Pharmacol. Rev. 57 (4), 427-450 (2005).
5. Jaquemar D, et al. J. Biol. Chem. 274 (11), 7325-7333 (1999).
Limitation
For research use only
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Code
OST00217W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
Sheep
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specificity
Specific for TRPA1.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Code
OST00217W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Sheep antibody to TRPA1
