Rb0136-281007-WS

A synthetic peptide from rat TRPV2 conjugated to blue carrier protein was used as the antigen.
The location of the epitope is highlighted in green.

Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1, Stretch-activated channel 2B, Sac2b, Vrl1

FUNCTION: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
SUBUNIT: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome.
TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level).
PTM: N-glycosylated.
PTM: Phosphorylated by PKA.
SIMILARITY: Belongs to the transient receptor family, TrpV subfamily.
SIMILARITY: Contains 3 ANK repeats.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Caterina M.J, et al. Nature 398:436-441(1999).
2. Rau,K.K., et al. J. Neurophysiol. 97 (4), 2651-2662 (2007).

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Specific for TRPV2.

Rat, mouse. Other species not yet tested.

Lyophilised. This product contains 0.02% benzalkonium chloride.

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet