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Code
OST00172W
$240USD
ID Tag
Rb837-070309-WS
Immunogen
A synthetic peptide from the 4th cytoplasmic loop of rat TRPM7 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Long transient receptor potential channel 7, LTrpC7, Channel-kinase 1, Transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK, Chak
Target
FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Binds 1 zinc ion per subunit.
SUBUNIT: Forms heterodimers with TRPM6. Homodimer.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen (at protein level).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Binds 1 zinc ion per subunit.
SUBUNIT: Forms heterodimers with TRPM6. Homodimer.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen (at protein level).
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Nadler M.J.S, et al. Nature 411:590-595(2001).
4. Villen J., et al. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
4. Villen J., et al. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Limitation
For research use only
- Click to download the Data Sheet
⚬ Products
Rabbit antibody to TRPM7
