TRPM7 antibody, LTRPC7 antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

Immunology

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OST00172W

$240USD

ID Tag

Rb837-070309-WS

Immunogen

A synthetic peptide from the 4th cytoplasmic loop of rat TRPM7 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

TRPM7_RAT

Also known

Long transient receptor potential channel 7, LTrpC7, Channel-kinase 1, Transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK, Chak

Target

FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Binds 1 zinc ion per subunit.
SUBUNIT: Forms heterodimers with TRPM6. Homodimer.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen (at protein level).

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Nadler M.J.S, et al. Nature 411:590-595(2001).
4. Villen J., et al. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).

Limitation

For research use only

Code

OST00172W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Specificity

Specific for TRPM7.

Spcs X-react.

Rat. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OST00172W