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Code
OST00170W
$240USD
ID Tag
Rb604-100808-WS
Immunogen
A synthetic peptide from the 1t cytoplasmic lop of rat, mouse TRPM7 (LTrpC7, Channel-kinase 1, TRP-PLIK, Chak) conjugated to an immunogenic carrier protein was used as the immunogen.
Accession
Also known
Long transient receptor potential channel 7, LTrpC7, Channel-kinase 1, Transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK, Chak
Target
FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Binds 1 zinc ion per subunit.
SUBUNIT: Forms heterodimers with TRPM6. Homodimer.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen (at protein level).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Binds 1 zinc ion per subunit.
SUBUNIT: Forms heterodimers with TRPM6. Homodimer.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen (at protein level).
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Nadler M.J.S, et al. Nature 411:590-595(2001).
2. Villen J., et al. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
2. Villen J., et al. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Limitation
For research use only
Code
OST00170W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for TRPM7.
Spcs X-react.
Rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OST00170W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to TRPM7
