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Code
OST00132G
$240USD
ID Tag
Rb494-290608-G
Immunogen
A synthetic peptide from 4th cytoplasmic loop of drosophila TRPL (Transient receptor potential like protein) conjugated to blue carrier protein was used as the antigen.
The location of the epitope is highlighted in green.
The location of the epitope is highlighted in green.
Accession
Also known
Transient receptor potential like protein, Transient-receptor-potential-like protein
Target
FUNCTION: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with trp-gamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins.
SUBUNIT: Forms heteromultimers with trp-gamma and, to a lower extent, with trp. Interacts with FKBP59 in vivo and is found in the inaD signaling complex.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note: In the dark, there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light, the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions.
SUBUNIT: Forms heteromultimers with trp-gamma and, to a lower extent, with trp. Interacts with FKBP59 in vivo and is found in the inaD signaling complex.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note: In the dark, there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light, the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Phillips A.M, et al. Neuron 8:631-642(1992).
Limitation
For research use only
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Code
OST00132G
$240USD
Unit size
500 ug
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
IgG
Clonality
Polyclonal
Isotype
Polyclonal, IgG
Applications
IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user.
Specificity
Specific for TRPL.
Spcs X-react.
Drosophila. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OST00132G
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Rabbit antibody to dr TRPL
